Synergistic Effect Of Surface Energy And Vitamin D_3 On Osteoblast Differentiation

摘要

Surfaces are important factors in the design of medical devices such as implants. Theoretically, pure TiO_2 surfaces should exhibit very high surface energy, resulting in reactivity and hydrophilic-ity. However, all commercially available Ti implant surfaces are hydrophobic due to adsorption of hydrocarbons and CO_2 during production, sterilization, and storage. These contaminations lower the surface energy, potentially reducing osteoblast differentiation and bone formation. In present study, a new modified Ti surface was developed with altered surface chemistry, resulting in increased hydrophilicity and surface energy. To test the hypothesis that surface energy can modulate osteoblast physiology, we compared the response of osteoblasts on traditional sand blasted and acid etched (SLA, R_a=4-5μm) Ti substrates to their behavior on uncontami-nated surfaces with identical mixed microtopographies but altered chemistry (modSLA).