Mean Pore Size and Compressive Strain Effects on the Permeability of Collagen-GAG Scaffolds: Cellular Solids Modeling and Experimental Results

摘要

Experimental results and the cellular solids model of scaffold permeability indicate that scaffold permeability increases with increasing pore size and decreases with increasing compressive strain. Previously we have shown an inverse relationship between pore size and specific surface area (SA/V). SA/V is likely a primary factor causing differences in permeability: scaffolds with greater SA/V exhibit increased resistance to fluid flow and therefore reduced permeability. The excellent comparison between experimentally measured and cellular solids model predicted scaffold permeability suggests that cellular solids modeling techniques can be used as a predictive model of scaffold permeability for many different scaffold architectures under a variety of physiological loading conditions.