Performance of Degradable Long-Fibre Composites for Craniofacial Bone Repair in a Calvarial Defect Model

摘要

This study has allowed us to confirm that the material shows considerable promise for progression to trials in patients. In particular, it is well tolerated in a clinically analogous environment and its degradation is sufficiently slow to overcome the deficiencies of competitor materials. The study was designed to test a number of options of candidate materials in the simplest craniofacial bony model. As such the thinness of the rat calvarium allowed only a 'butt' end joint between bone and material, micromovement was inevitable, interface contact very limited and a full assessment of the ability of the material to integrate with bone was not possible. The close proximity of bone to material and surface erosion of implants at 26 weeks indicates a promising bone material interface, this will investigated further in a more clinically analogous model.