Interpenetrating Networks Containing Gelatin Modified with PEGylated RGD and Soluble KGF: Synthesis, Characterization, Application in in vivo Critical Dermal Wound

摘要

By including PEGylated-RGD and KGF-1 in the composition of the IPN, the healing of the wound progressed faster and the composition of the regenerated tissue was more favorable in structure as compared to wounds treated without those factors. These results indicate that both soluble and immobilized bioactive factors can be incorporated into our IPN platform to enhance the rate and the quality of dermal wound healing.