Drug Delivery Using Biodegradable Tyrosine-based Nanospheres

摘要

An evaluation of the tyrosine-based amphiphilic ABA triblock copolymers nanospheres exhibited preferential strong complexation with hydrophobic materials. Our results suggest that the nanospheres act as an effective sink for absorbing and binding hydrophobic drugs and the association efficiency increases with drug hydrophobicity and/or hydrophobicity of the middle block of the nanospheres. The delivery of chemotherapeutic agents with varying Log D values to the tumor cells in vitro was confirmed by growth inhibition of KB human carcinoma cells.