Preparation of 3D Porous Collagen Scaffold around Implantable Biosensor for Improving Biocompatibility

摘要

In this study, type Ⅰ collagen scaffolds were crosslinked by GA and/or EDCA. These crosslinked scaffolds are stable both in vitro and in vivo for at least 4 weeks. Also, scaffold application around glucose sensors did not significantly affect the sensors sensitivity. Our next step will be to use the scaffolds to deliver anti-inflammatory drug and angiogenic growth factors (e.g. VEGF, PDGF) in order to create a controlled local tissue environment around sensors with minimum inflammation and fibrosis but with increased blood vessel density.