Comparison of Glycosaminoglycan-Targeted Fixation Chemistries and their Effects on Bioprosthetic Heart Valve Cuspal Tissue

摘要

GAG stabilization in valvular tissue is possible using targeted fixation chemistries. Crosslinking of GAGs preserves hydration status while maintaining adequate collagen stability. It is apparent that some in vitro and in vivo GAG loss does occur over time in all fixation groups to different extents: however GAG stabilization occurs and may be significant enough to improve the biomechanics and longevity of the bioprosthetic heart valve. Future investigations will include determining mechanical properties and in vitro durability of mechanically fatigued GAG stabilized valves. It is expected that bioprosthetic heart valves in which GAGs are chemically crosslinked will exhibit increased durability in vivo.