NANOBIOTECHNOLOGY FOR IMPROVING TRANSDERMAL DRUG DELIVERY

摘要

Skin delivery of certain medical products during treatment of local skin disease is one of the oldest ways to administer medicine, but skin delivery of medical products for transdermal carriers is relatively new and often used. The rapid development of transdermal carriers in the past several years is due to the advantages of transdermic administration over the classic oral administration. The difficulty in transdermic administration is represented by skin penetration of the products, because skin, through it's nature, acts as a barrier in controlling the loss of water, electrolytes and other substances and also in preventing the penetration of medical substances from the outside environment. In order to enhance skin permeability for transdermal portage of medical substances, several methods, both passive and active, have been developed. This review aims to examine classic and novel modalities for skin delivery of drugs, including the development of dermal/transdermal nanocarriers.