Pharmacokinetics, metabolism and tolerance of intravenous paracetamol in early life

摘要

Effective analgesia in neonates is still hampered due to the lack of data on pharmacokinetics and -dynamics of analgesics in this specific population. To a certain extent, this is even true for paracetamol. An intravenous formulation might improve prediction of concentration and consequent effect compared to enteral administration. There are limited pharmacokinetic data available concerning intravenous paracetamol in neonates that can be used to determine dosing while dosing regimens used in clinical practice vary from manufacturer recommendations. The impact of covariate information on dosing is uncertain. In this paper, we summarize the consecutive datasets we made to document aspects of pharmacokinetics, metabolism and aspects of safety (hepatic tolerance, haemodynamic stability and effects on body temperature) during exposure to intravenous paracetamol in neonates.