EU Essential Oils Hazard Classification: Quantitative Multicomponent GCMS Analysis

摘要

A quantitative analysis method has been developed for EU hazard classification requirements for essential oils. Method uses dual column GCMS to analyze for 77 analytes. Quantitation is based on full scan extracted ion technique and internal standards. A wide calibration range is needed to cover the range of concentrations observed in nature. Analytical data are processed automatically using a software routine. This paper demonstrates aspects of the method, including dual column approach, calibration, validation, identification criteria and automated data processing. Also, a comparison between full scan extracted ion and SIM quantitation is discussed.