The Design of a Half-bridge Series-resonant Type Heating System for Magnetic Nanoparticle Thermotherapy

摘要

Application of magnetic materials for hyperthermia of biological tissue has been known, in principle, for more than four decades. Many empirical works were done in order to confirm a therapeutic effect on several types of tumors by performing experiments with animals or using cancerous cell cultures. The main idea of magnetic nanoparticle (MNP) thermotherapy is to utilize 7-to 50-nm diameter of ferric oxide (Fe3O4) particles which are heated up to 42℃ under AC magnetic field for cancer therapy applications. In order to achieve the goal of killing cancer cells using the AC magnetic field, we designed a heating system to generate magnetic field which can be focused and frequency adjustable. This study adopts the half-bridge series-resonant type circuit as the core scheme of the heating system, and utilizes the frequency-adjustable design to conduct the heating experiment. The experiment results show that the designed coil and the heating system can warm up the magnetic nanoparticle 6℃ in 32 minutes.