Amoxicillin Nanoparticles Prepared by SCF Technology

摘要

Current, the traditional methods to control the particle size have many disadvantage, such as large quantities of residual organic solvent, wide size distribution. So a growing concern of using supercritical fluid (CO2) crystallization to manufacture microparticles, because of its relatively low critical temperature and pressure (Tc=31.1℃ and Pc=73.8 Mpa) , small particle size, narrow size distribution, no residual solvent. Solution enhanced Dispersion by supercritical fluid (SEDS) is belong to supercritical fluid crystallization technique, works on the antisolvent principle. In this way, high mass transfer rates are achieved with a high ratio of supercritical fluid to solvent. This makes the SEDS a highly controlled process. Amoxicillin is a antibiotic used in treatment of certain infections caused by bacteria. It is not easily soluble in water, which leads to low bioavailability. This research used the SEDS process to manufacture nanoparticles of amoxicillin to increase the surface area for high bioavailability and reducing the dosage. This paper research how to manufacture nanoparticles by change the conditions such as temperature, pressure, solubility in NMP. Samples were analyzed using SEM, through the image we confirm producing nanoparticles of Amoxicillin from 200-400 nm, shape with spherical and have no reunion, achieve the purpose of the research. The paper supply some experience for manufacturing nanoparticles of drug.