Clinical significance of pharmacokinetics in patients with deep mycotic infection

摘要

85 patients with deep mycotic infection were confirmed by positive cultures and directmicroscopic exmaination. In order to investigate the ocrrelation between pharmacokinetics and clinical effects, fluconazole (FCZ) concentrations in blood, urine and saiva were determined in 19 normal volunteers who intravenously injected by 300mg fluconazole. The results showed that mst patients suffered from primary diseases and congenital immune defect was found in 5 cases. Prolonged use of high-dose antibiotics, corticosteroid, immunosuppressant, cytotoxic drugs and radiation treatment might result in acquired immunodeficiency, and flora imbalance even superinfection. These data indicated that congenital immune defect and secondary dysfunction of host defense appeared to be impoten factors for deep mycotic infection. Moreover, groad-spectrum antibiotics were used in 95