The Use of Thermogravimetry to Study Thermal Behavior of Acetylsalicylic Acid in Tablet Mixtures

摘要

The thermal behavior of acetylsalicylic acid (ASA) was investigated in presence of tabletrnexcipients and others active materials. Samples of pure ASA and tablets from differentrnmanufactories were analyzed by thermogravimetry (TG). It was observed, in some of the tabletsrnanalyzed, that the first decomposition of ASA, on TG curve, is independent of the excipients.rnThermogravimetry is proposed as a technique for ASA determination in pharmaceutical tabletsrnmixtures. The results of TG were compared with titration analysis.