A unified approach of mixed-effects model has been recently proposed for clustering correlated genes from different kinds of microarray experiments. With the so-called EM-based MIXture analysis WIth Random Effects (EMMIX-WIRE) model, both the gene-specific and tissue-specific random effects are taken into account in the (mixture) modelling of microarray data. In this paper, we focus on the applications of the EMMIX-WIRE model to the cluster analysis of microarray data with repeated measurements. In particular, we investigate various forms of covariance structure commonly applicable for replicated microarray data and compare their impact on the final clustering results, using a real data set of microRNA profile and a published yeast galactose data set with known Gene Ontology (GO) listings.
University of Queensland, Brisbane, QLD, Australia;
s Hospital, Boston, MA;
机译:基于贝叶斯混合模型的复制微阵列数据聚类
机译:基于贝叶斯混合模型的复制微阵列数据聚类
机译:具有因子分析器协方差结构的通用位置模型的混合物,用于对混合类型数据进行聚类
机译:通过各种协方差结构的随机效果模型的混合物来聚类复制的微阵列数据
机译:两部分混合模型,用于零膨胀纵向测量,具有不同的随机效应和事件数据时间。
机译:BREM-SC:用于联合聚类单细胞多组学数据的贝叶斯随机效应混合模型
机译:错误假设对重复测量数据非线性混合模型中随机效应和/或残差的协方差结构的影响