Silver Nanorod Arrays as High Sensitive SERS Substrates for Viral Detection

摘要

The aligned silver nanorod array substrates prepared by the oblique angle deposition method are capable of providing extremely high enhancement factors (～10~8) at near-infrared wavelengths (785 nm) for a standard reporter molecule 1,2 trans-(bis)pyridyl-ethene (BPE). The enhancement factor depends strongly on the length of the Ag nanorods, the substrate coating, the polarization of the excitation light, as well as the incident angle. With the current optimum structure, we demonstrate that the detection limit for BPE can be lower than 0.1 fM. The applicability of this substrate to the detection of bioagents has been investigated by looking several viruses at low quantities (～0.5uL). Different viruses have different fingerprint Raman spectrum.