Steps towards a patient individual geometric model of the bronchial-tree used for functional simulations

摘要

Based on clinical CT-data a patient individual model of the bronchial-tree is constructed, incorporating information on irregular dichotomic branching of the airway bifurcations. Combining this geometric model with analytical models of transport and uptake of gas a patient individual outline of ventilation of the lung and the individual time course of inhalation is given. Conjunctions to multi-breath washout analysis are deduced. Central purpose of the presented model is to assess the significance of patient individual local airway geometry on the global ventilation of the lung and the resulting uptake of inhaled gases in the gas exchange regions of the lung.