Treatment of rat Walker-256 carcinosarcoma with photodynamic therapy and endotoxin irradiated with high-energy electrons

摘要

Abstract: Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinosarcoma receiving sole treatment photodynamic therapy (PDT), irradiated endotoxin (R-LPS), native-endotoxin (N-LPS), or associated therapy (PDT $PLU R-LPS) and the control batch (saline) consisted of animals with untreated Walker-256 tumors. The results were as follows: the sole treatment (PDT, R-LPS, N- LPS) gave survival rates between 56.3 and 60.7% and cure rates ranging from 32.1 to 37.5%. The `combined' therapy in multiple doses increased significantly (88.6%) the survival rate of tumor bearing rats as well as the highest incidence of complete tumor regression (71.4%). This work demonstrates that `combined' photodynamic and immunotherapy with irradiated endotoxin stimulates cell-mediated antitumoral activity and induces changes in the tumoral incidence in Walker-256 carcinosarcoma in the rat model. !17