Studies on the Sonosensitization Mechanism of Ultrasound with ATX- 70 in Sonodynamic Therapy

摘要

Sonodynamic therapy (SDT) is an effective method for cure tumors, but its mechanism is not clear up to now. In this work, the mechanism of SDT is analyzed by study the reaction between ultrasound and the gallium-porphyrin analogue ATX-70 experimentally. Results show that the ATX-70 is likely to play three roles in SDT. One is that the sonolumiescence (SL) react with ATX-70 directly, the action of ATX-70 is similarly to a sort of photosensitize. The other is that the high temperature produced in the bubbles at collapse makes ATX-70 into excitated states, the excitated ATX-70 react with the dissolved oxygen in liquid and produce oxygen free radicals. The third is that ATX-70 plays a role of surfactant in the process of cavitation and makes the cavitation become easily, lead to more high-energy hydroxide radicals are produced.