Balloon photodynamic therapy of esophageal cancer: effect of increasing balloon size

摘要

Abstract: We have found that an esophageal centering balloon improves light delivery to esophageal mucosa during photodynamic therapy (PDT). However, balloon pressure on esophageal mucosa could possibly reduce mucosal blood flow and oxygenation, therefore reducing the photodynamic therapy effect. Studies were performed in the canine esophagus of 10 animals to investigate whether increasing the size of the centering balloon and hence the pressure on esophageal mucosa would alter the tissue effect of PDT. It was concluded that increasing balloon size resulted in reduced tissue damage when mucosal equivalent light dose was administered during photodynamic therapy. Proper sizing of centering balloons will be necessary for balloon PDT of esophageal mucosal dysplasia or cancer. !4