Antithrombotic and thrombolytic effects of antithrombin: comparison with either heparin or defibrase

摘要

Abstract: Anti-thrombotic and thrombolytic effects of anti-thrombin agent (Argatroban;Arg 0.5 mg/kg) was evaluated by angioscopy and compared with heparin (250 U/kg). Occlusive thrombus was produced in canine iliac artery by balloon injury. At another side, balloon denudation was attempted at 20 minutes after the administration of the agent. One hour thrombus was control. Angioscopic percent luminal obstruction with thrombus reduced by Arg (from 69 to 32%, P $LS 0.0001), but not by heparin (from 53% to 59%). Both agents had antithrombotic effects and prevented thrombus formation. The activated partial thromboplastin time (APTT) prolonged to 190% with argatroban and 1253% with heparin (P $LS 0.0001). Thus, antithrombin agent has both preventive effect of thrombosis and thrombolytic effect without marked prolongation of the APTT.!7