Depth-resolved simplified characterization of collagen depletion in dermis with polarization sensitive optical coherence tomography applicable to non-laboratory conditions

摘要

A further insight into the prior concept of polarization sensitive optical coherence tomography system intended for non-laboratory conditions is brought forward and an experimental proof-of-concept is presented. A phenomenological model is adopted from the theory of light depolarization in crystalline polymers and modified to yield a simplified algorithm for mapping depolarization ratio in dermis. The algorithm could distinguish between dermal layers with depleted collagen content and normal dermis of normal perilesional skin. Dermis is simulated by bireringent lamellae of collagen arranged chaotically in multiple layers parallel to the skin surface. Both the design concept and the model imply the sub-millimeter tumor thickness as a proofed prognostic factor and an important criterion for complementary functional diagnostics of skin cancers at their early phase of vertical growth. Choice of the model is inspired by similarity of structural and optical properties between liquid-crystal collagen fibers in dermis and birefringent crystalline lamellae in polymer materials. The numerical computation based on the model allowing for real characteristics of dermis gives plausible interpreting of depolarization peculiarities caused by collagen depletion. Feasibility is discussed of exploiting fiber optic analogs of achromatic retarders. Fabrication of the fiber retarders is shown to be realistic by making use of the photonics technology possessed by the authors.