Synthesis and Properties of Magnetic Nanoparticles with Potential Applications in Cancer Diagnostic

摘要

In this paper we prepared three types of magnetic nanoparticles with potential applications in cancer diagnosis: cobalt nanoparticles, cobalt-nickel alloy nanoparticles and mixed oxide particles, i.e. magnetite nanoparticles. For cobalt nanoparticles we have used the reverse micelles technique as "nanoreactors" inside which salt reduction and particle growth occurs. Particles of cobalt-nickel alloy have been prepared by co-reducing the corresponding salts. The reduction methods yield a dispersion of nanocrystals in liquids and involve the need for a ligand shell or a capping layer to prevent aggregation. The particles of magnetite were prepared by boiling in reflux of a mixture formed by γ-Fe_2O_3 and Fe(Ⅱ) salt (citrate or sulphate). The magnetic behavior of Co nanoparticles NiCo nanoparticles and magnetite nanoparticles reveals as the obtained magnetic nanoparticles can be used to enhance the signal from magnetic resonance imaging examinations, as diagnostic tools of cancer tumors and targeting treatment of diseases.