Photo-Enhanced Luminescence in Bio-conjugated Quantum Dots for Ovarian Cancer Biomarkers

摘要

Luminescent semiconductor quantum dots (QDs) can be readily conjugated with biomolecules and serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer, which represents the most lethal gynecologic malignancy. We report on the luminescence characterization of the bio-conjugated QDs with CA125 antigen using linkage molecules. Kinetic curves of the bio-conjugated 655nm QD luminescence show both photo-enhancement and photo-degradation. Photo-enhancement is measured at various laser power densities, temperatures and laser wavelengths. The mechanism of the PL enhancement is discussed.