Stochastic trigger for clathrin-coated vesicle biogenesis

摘要

Kinetic aspects of receptor-mediated endocytosis are identified, particularly as relating to the stochastic formation and released of clathrin coated vesicles at the plasma membrane. We discuss how one might account for the coordinated steps of this process, including receptor activation, association with adaptor proteins, coat formation, and the role of phosphoinosotide metabolism as a regulatory mechanism. In anticipation of building a detailed mathematical theory, we discuss an earlier treatment of the way threshold fluctuations affect the firing probability of nerve axons (H. Lecar, and R. Nossal, Biophys. J. 11, pp. 1048—1067, 1971), in which equations were analyzed by distinguishing different time-scales to identify pertinent kinetic variables