Vibrational Spectroscopy Studies on Biologically Relevant Molecules: From Anticancer Agents to Drugs of Abuse

摘要

Vibrational spectroscopy (both Raman and Inelastic Neutron Scattering), coupled to quantum mechanical calculations, is used in order to perform a thorough analysis of several biologically relevant molecules, such as chemotherapeutic agents, biogenic polyamines and their metal chelates, cardiovascular protectors, non-steroid anti-inflammatory drugs (NSAID's), drugs of abuse and phenolic compounds. The conjugation of these techniques yields valuable information regarding the structural preferences of the systems under investigation, which may help establish the structure-activity relationships (SAR's) ruling their biological function.