Microparticles on the Basis of Segmented Polyurethanes for the Treatment of Tuberculosis

摘要

The objective of the research is to develop a new drug delivery system based on polyurethane (PU) microparticles for the treatment of tuberculosis by pulmonary administration to the lungs. The synthesis and characterization of polyurethane microcapsules are studied making use three molecular weight polyethylene glycol (PEG) and tolylene-2,4-diisocyanate (TDI). Antitubercular drugs such as isoniazid was incorporated into the polyurethane microcapsules. The effects of nature and concentration of drug and diols were studied by electronic microscope and size distribution by dynamic light scattering analysis. It was shown that the size of microcapsules at maximum distribution band increases also with the PEG length. The size of polymeric microcapsules and size distribution are important factors for their application for pulmonary administration of drug by respiratory way. The size of microparticles is limited to 1-10 μm. Particles of such size are mainly to be placed in the periphery of the lung and must be phagocytized by alveolar macrophages, the primary site of tuberculosis infection.