Nanoplex~TM biotags: Near-IR Excited, Highly Multiplexed Nanoparticulate Optical Detection Tags for Diagnostic Assays

摘要

Oxonica has developed a novel optical detection tag for use in point of care diagnostics, cellular imaging assays, and life science assays. Nanoplex~TM biotags are silica coated Au nanoparticles that, by virtue of surface enhanced Raman scattering (SERS) active molecules at the glass-metal interface, act as detectable tags. Many unique biotags can be generated by varying the Raman active molecule adsorbed on the nanoparticle, thus allowing multiplexed detection to be performed. Importantly, because the biotags are excited in the far red or near-IR, and can be detected with low-cost instrumentation, they are ideal for performing assays in both tissue and whole blood. We will present data showing the versatility of this novel nanotechnology, and the applications to diagnostics.