Temperature Controlled Grafted Polymer Network Incorporated With Magnetic Nano Particles To Control Drug Release Induced By An External Magnetothermal Trigger

摘要

A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event was developed. The desirable carrier will have minimal release at 37 °C so that the system can be localized (e.g., to cancer cells) prior to activation of the delivery of medication. The grafted hydrogel system is shown to exhibit a desirable positive thermal response with an increased drug diffusion coefficient for temperatures higher than physiological temperature.