DISPOSABLE HEALTHCARE CHIP ALLOWING MULTI-ITEM DIAGNOSTICS IN A TRACE OF BLOOD

机译：一次性使用卫生保健片，可在多种血液中进行多项目诊断

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A disposable and cheap healthcare chip allowing multi-item diagnostics such as pH, K~+, Na~+, Blood Urea Nitrogen (BUN) and Glucose, in trace of blood has been developed on the basis of study on potentiometric and amperometric sensors on printed carbon electrodes. High ion selectivity and stability of Na~+, and K~+ ion sensors were obtained by controlling both mole ratio of anion-exclusion agents to ionophores and grain size of carbon particles and its binder on printed carbon electrodes. The design of channels with a blanched capillary was effective for preventing mutual interference due to the enzyme-reaction. The electrochemical blood diagnostics chip employing screen-printed carbon electrodes on a polymer film allowed to achieve a cheap, multi-item and simultaneous measurement.

机译：在对电位计和安培计传感器进行研究的基础上，已开发出一种可抛弃的廉价医疗保健芯片，可对多种微量元素进行诊断，例如pH，K〜+，Na〜+，血尿素氮（BUN）和葡萄糖。印刷碳电极。通过控制阴离子排阻剂与离子载体的摩尔比以及印刷碳电极上碳颗粒及其粘合剂的粒径，可以获得高离子选择性和Na〜+和K〜+离子传感器的稳定性。毛发变白的通道设计可有效防止酶反应引起的相互干扰。电化学血液诊断芯片在聚合物膜上采用丝网印刷的碳电极，可实现廉价，多项目的同时测量。

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《muTAS 2003 International Conference on Miniaturized Chemical and Biochemical Analysis Systems v.1; 20031005-20031009; Squaw Valley,CA; US》|2003年|P.403-406|共4页
会议地点 Squaw ValleyCAUS
作者
Madoka Takai; Satomi Shinbashi; Hiroki Ogawa; Akio Oki; Masao Nagai; Yasuhiro Horiike;
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作者单位

Department of Materials Engineering, The University of Tokyo;

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会议组织
原文格式 PDF
正文语种 eng
中图分类生物化学技术;
关键词
blood analysis; disposable healthcare chip; electrochemical detection; multi-item diagnostics;

机译：血液分析;一次性保健芯片;电化学检测;多项目诊断;

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专利

1. Cheap as chips: are sensors the next healthcare disposables? [J] . Adrian Wilson Nonwovens Report International . 2014,第3期

机译：芯片便宜：传感器是下一个医疗一次性产品吗？
2. Disposable Lab-on-a-chip Device for Accurate Disease Diagnostics [J] . Inside R & D . 2018,第feba2期

机译：用于精确疾病诊断的一次性芯片实验室设备
3. Thermoplastic Microfluidic Device for On-Chip Purification of Nucleic Acids for Disposable Diagnostics [J] . Arpita Bhattacharyya, Catherine M. Klapperich Analytical chemistry . 2006,第3期

机译：片上纯化核酸的热塑性微流控装置，用于一次性诊断
4. DISPOSABLE HEALTHCARE CHIP ALLOWING MULTI-ITEM DIAGNOSTICS IN A TRACE OF BLOOD [C] . Madoka Takai, Satomi Shinbashi, Hiroki Ogawa, International conference on miniaturized chemical and biochemical analysis systems . 2003

机译：一次性医疗保健芯片允许多项诊断在一丝血液中
5. On -chip blood cell/plasma separators on polymer lab -on -a -chip for point-of-care clinical diagnostics [D] . Han, Jungyoup 2006

机译：聚合物实验室芯片上的血细胞/血浆分离器，用于即时临床诊断
6. A Disposable Blood-on-a-Chip for Simultaneous Measurement of Multiple Biophysical Properties [O] . Yang Jun Kang 2018

机译：同时测量多种生物物理特性的一次性片上血液
7. : "This paper deals with the functionality of the flaked stone assemblages from several Neolithic sites of the NE of the Iberian Peninsula. The chronological framework ranges from the mid-6th to the mid-4th millennium cal. BCE, which corresponds to the Early and Middle Neolithic. This long period ranges from the arrival of the first farming communities in the Iberian Peninsula, around 5600-5500 cal. BCE, to 3600-3500 cal. BCE, two millennia later, when Neolithic communities had stably occupied most of the available territory, from the mountainous areas of the Pyrenees to the coastal areas of the Mediterranean.In this context, the NE of the Iberian Peninsula is one of the areas where a major number of use-wear analyses have been carried out, especially for what concerns the Neolithic period. This is mainly due to the interest shown by the directors of the excavations and by the Spanish use-wear specialists as well; both participated and cooperated in order to enlarge the number of contexts studied, making the NE of the Iberian Peninsula one of the areas of Europe with the largest number of ‘functional studies’. As a result, today we have a reliable picture of the type of lithic tools used by the first farming groups, how they were used, and which needs they were satisfying.The methodology employed for this type of analysis is today broadly shared by most use-wear specialists. A stereoscopic microscope is used together with a reflected-light microscope for the analysis of the archaeological specimens. Afterwards, the observed use-wear traces are compared with the traces from experimental tools. This study primarily made use of the tools preserved at the ‘Traceoteque’ of the Institución Milà y Fontanals of the CSIC of Barcelona.This paper presents the results obtained for the different types of analysed sites and the relative lithic assemblages. In this way, tools from different contexts are compared: open-air sites, caves and rock-shelters, pit-sites, burials, and mining sites. Such a diversity of contexts allowed for the exploration of the existence of recurrences and differences in the functionality of the lithic tools from one site to another. The results obtained have also provided information on some aspects related to the economic processes carried out at the different sites, caves, rock-shelters and open-air contexts. It has been possible to gain fresh data on the types of tasks carried out and their relative importance for each site, their relation with the geographical and environmental context and the natural resources available there. In addition, analysing tools recovered from burials – mainly individual inhumations – provided information on the relationships between the buried individuals and the working tools, in particular exploring the relationships between sex and age patterns and the types of tools deposited as goods.In conclusion, use-wear analysis allowed for the exploration of a variety of issues; from technical aspects related to the production and management of the lithic resources to social aspects related to the subsistence activities and the individuals that carried them out." [O] . Gibaja Bao, Juan Francisco, Mazzucco, Niccolo 2015

机译：：“本文研究了伊比利亚半岛东北部几个新石器时代遗址的片状石材组合的功能。时间框架从公元前6世纪中叶到4世纪中叶，分别对应于早期和早期。新石器时代中期，这段时间的长短是从伊比利亚半岛的第一个农业社区到来，大约在公元前5600-5500 cal，到了两千年后的3600-3500 BCE，当时新石器时代的社区稳定地占据了大部分可用土地。从比利牛斯山脉山区到地中海沿岸地区。在这种情况下，伊比利亚半岛东北部是进行过大量使用磨损分析的地区之一，尤其是在关注方面新石器时代，这主要是由于发掘负责人和西班牙使用服装专家表现出的浓厚兴趣；他们参与和合作以扩大孔蒂的数量xts进行了研究，使伊比利亚半岛的NE成为“功能研究”数量最多的欧洲地区之一。结果，今天我们可以可靠地了解第一批耕作小组使用的石器工具的类型，使用方法以及它们满足的需求。今天，大多数使用方法广泛共享用于这种类型的分析的方法穿专家。立体显微镜与反射光显微镜一起用于分析考古样本。然后，将观察到的使用磨损痕迹与实验工具的痕迹进行比较。这项研究主要利用了巴塞罗那CSIC的米拉·丰塔纳尔研究所的“ Traceoteque”中保存的工具。本文介绍了针对不同类型的分析地点和相对石器组合所获得的结果。通过这种方式，可以比较来自不同环境的工具：露天场所，洞穴和岩石避难所，露天场所，埋葬场所和采矿场所。如此多样的上下文允许探索重复性的存在以及从一个站点到另一个站点的石器工具的功能差异。所获得的结果还提供了与在不同地点，洞穴，避难所和露天环境中进行的经济过程有关的某些方面的信息。可以获得有关所执行任务的类型及其对每个站点的相对重要性，它们与地理和环境环境以及那里可用自然资源的关系的新数据。此外，对从墓葬中回收的工具（主要是个人遗体）进行分析，可提供有关被掩埋的个体与工作工具之间关系的信息，尤其是探索性别与年龄模式之间的关系以及作为商品存放的工具的类型。磨损分析允许探索各种问题；从与石器资源的生产和管理有关的技术方面到与自给活动及其实施者有关的社会方面。”

DISPOSABLE HEALTHCARE CHIP ALLOWING MULTI-ITEM DIAGNOSTICS IN A TRACE OF BLOOD

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