Time-domain diffuse fluorescence tomography of CT-analogous scheme: an experimental validation

摘要

A fiber-based non-contact scheme of the time-domain diffuse fluorescence yield and lifetime tomography is described that combines the time-correlated single photon counting technique for high-sensitive, time-resolved detection and CT-analogous configuration for high throughput data collection. A pilot validation of the methodology is performed for two-dimensional scenarios using simulated and experimental data. The results demonstrated the potential of the proposed scheme in improving the image quality.