A study on exposure levels and influencing factors of endocrine disruptors in Korean adults - The 3rd cycle of Korean National Environmental Health Survey (KoNEHS)

摘要

Bisphenol A and phthalate metabolites are endocrine disruptors that enter the human body and interfere with normal endocrine functions (e.g. reproductive and developmental processes). This study aims to investigate exposure levels and effects of bisphenol A and phthalate metabolites, based on Korean National Environmental Health Survey (KoNEHS, 2015-2017). In this study, those taking obesity and/or metabolic syndrome medicine were excluded from the 3,787 subjects (233 districts) in 3rd KoNEHS. Urinary Bisphenol A and phthalates were analyzed by LC-MS/MS. DEHP metabolites were calculated by summing MEOHP and MEHHP. Body mass index(BMI) was divided into four groups : low body weight(25.0). Statistical analysis was performed using GM, 95% confidence interval. Significance was determined by kruskal-wallis test. The Bisphenol A level was 1.18 ug/L on average, while it was 1.33 ug/L for males, higher than 1.04 ug/L for females. Bisphenol A concentrations showed a significant increasing trend(p<0.0001) with BMI: 1.01,1.17, and 1.37 pg/L for the normal, pre-obesity, and obesity groups, respectively. This trend was more apparent in females. DEHP metabolites had a similar relation with BMI(21.2, 24.0, and 25.6 ug/L for the normal, pre-obesity, and obesity groups, respectively) with the average concentration of 23.5 ug/L. Consumption frequency of canned beverage, plastic-bottled beverages, and frequency of plastic container use were considered, but did not show statistically significant relationship with these chemicals in this research. This study examined exposure levels of bisphenol A and DEHP metabolites, and confirmed their associations with BMI. The results can be used as basic data to understand health effects of endocrine disruptors.