The Impact of Indoor Fine Particles on Body Mass Index, Waist Circumference, and Triglyceride of Korean Housewives Cohort Study: Preliminary Results

摘要

Background: Few studies have evaluated the associations between indoor particulate matter (PM) and cardiovascular disease (CVD) risk factors in housewives who are exposed to large amount of indoor PM as they spend great deal of time doing house chores such as cooking and cleaning. Hence, we investigated the association between indoor PM and the CVD risk factors in housewives. Methods: We recruited 25 housewives (January to March 2018) in Ulsan, an industrial city, Republic of Korea. We measured indoor PM2.5 (particulate matter<2.5 in diameter) concentrations at participant's house using weight method for 24hrs. Thereafter, participants were invited to hospital for a physical examination and collecting bio specimens (blood and urine) to analyze inflammatory markers, lipid profile, fasting insulin, and fasting glucose. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), body mass index (BMI), and metabolic syndrome (MS) were further defined. The association between PM2.5 and CVD risk factors were evaluated using multiple linear regression or multiple logistic regression analysis. Results: The average indoor PM2.5 concentration was 42.7 μg/m3 (range: 13.2-143.2 g/m3). BMI (beta=0.06; 95% confidence interval (Cl)=0.00-0.11), waist circumference (beta=0.15; CI=0.03-0.27), and triglyceride (beta=1.26; Cl=0.19-2.33) were significantly associated with 1 g/m3 increase of indoor PM2.5 The association between MS and PM2.5 was marginally significant (odds ratio=1.09; Cl=1.00-1.20). Blood pressure, C-reactive protein, total cholesterol, low density lipid cholesterol, fasting insulin, and HOMA-IR were increased with PM2.5 concentrations, but not significant. Conclusions: In this preliminary study, several CVD risk factors are likely to be associated with an indoor PM2.5 exposure in housewives. This study will be extended by recruiting about 300 housewives by 2019 to clarify this association.