In vitro Evaluation of a Novel Injectable Thermo-Responsive Polymeric Hydrogel for the Delivery of Self-Assembly Peptide Nanoparticles Containing an Osteoconductive Agent

摘要

We have successfully produced a thermo-responsive polymer with the potential to behave as both a scaffold and delivery vehicle. Furthermore, RALA peptide was capable of forming NPs with TCP, which were stable across a range of temperatures and over an extended duration. Upon fine tuning of the hydrogel formulation, the degradation pattern and NP release from the hydrogel in vitro will be studied. The dual functionality of the hydrogel as a scaffold for bone regeneration and a delivery vehicle for osteoconductive NPs will finally be assessed in vivo.