Resorbable Temperature-Responsive Hydrogels Are Biocompatible Controlled Release Vehicles

摘要

PNDJ hydrogels were well-tolerated following injection in both soft and hard tissue sites, leading to minimal tissue reaction upon in vivo implantation. There is minimal tissue reaction and foreign body response to the polymer, similar to many other biomaterials. The desirable swelling properties identified in vitro, and short degradation time of the material are maintained in the in vivo setting. This study provides reliable evidence that PNDJ hydrogels are likely to be biocompatible for intramedullary and soft tissue drug delivery.