Distinct Local Macrophage Phenotypes Are Associated With Divergent Tissue Remodeling Outcomes Following Implantation of Biologic Scaffolds

摘要

The results of this study showed that each test article was associated with a distinct host tissue remodeling response. Each test article was also associated with differences in macrophage polarization, suggesting that different macrophage populations are associated with different mechanisms of tissue remodeling. Further, the macrophage response to individual test articles was not observed to affect (or be affected by) the response to other test articles suggesting that macrophage polarization occurs locally at the remodeling site and is, therefore, likely a function of macrophage-scaffold interactions.