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Development of Supercritical CO_2-Treated Human Amniotic Membrane Combined with Adipose Derived Stem Cells for Wound Treatment

机译:超临界CO_2处理的人羊膜的研制联合脂肪衍生干细胞伤口治疗

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In this study we have shown through physical, biochemical and histological analysis that SCCO_2 treatment provides a viable method to produce sterile AM while still retaining characteristics of native AM. Additionally, we have shown that hASCs readily attached and proliferated on the SCCO_2-treated membrane. In vivo studies revealed that an AM-hASCs construct promotes wound healing as evidenced by improved re-epithelalization and increased vascular networks within the wound bed. These results demonstrate that SCCO_2-treated AM in combination with hASCs are efficacious in wound healing and skin regeneration.
机译:在这项研究中,我们通过物理,生化和组织学分析显示,SCCO_2治疗提供了一种在仍然保持天然AM的特征的同时产生无菌的可行方法。另外,我们已经表明,在SCCO_2处理的膜上容易地附着和增殖的HASC。体内研究表明,AM-HASCS构建体促进伤口愈合,如改进的重新上皮化和伤口床内的血管网络所证明。这些结果表明,与HASC组合的SCCO_2治疗的AM在伤口愈合和皮肤再生中是有效的。

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