Co-delivery of GDNF and NGF is superior to the delivery of GDNF alone for enhancing nerve regeneration in vivo

摘要

Functional regeneration of transected human peripheral nerve remains to be improved To this aim, we have developed collagen (native or cross-linked) nerve conduits (NCs) delivering glial cell line-derived neurotrophic factor (GDNF) alone or in combination with nerve growth factor (NGF), and tested their effect on nerve regeneration in rats. Combined delivery of GDNF and NGF promoted nerve regeneration to a greater extent than delivery of GDNF alone. The results support our previous in vitro observations, suggesting the synergistic action of GDNF and NGF on axonal outgrowth.