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1H-NMR detection of mobile lipids in live cells as a non-invasive screen for apoptosis induced by drug-loaded liposomes and micelles

机译:1H-NMR检测活细胞中的移动脂质作为由药物脂质体和胶束诱导的细胞凋亡的非侵入性筛选

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An increase in mobile lipids (ML) was investigated by NMR as an assay to screen for the drug-induced apoptosis. BT 20 and MCF 7 breast cancer cells treated with paclitaxel (PCL)-loaded liposomes or micelles, respectively, showed a strong increase in the ML signals, compared to untreated cells or cells treated with empty liposomes or micelles.
机译:通过NMR研究了移动脂质(ML)的增加,作为药物诱导的细胞凋亡的筛选的测定。与用空脂质体或胶束处理的未处理的细胞或细胞相比,分别用紫杉醇(PCL) - 加载的脂质体或胶束处理的BT 20和MCF 7乳腺癌细胞分别对ML信号进行强烈增加。

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