Improved In Vitro and In Vivo Antitumor Activity of 5-fluorouracil-loaded PEGylated Bolasurfactant Niosomes

摘要

Innovative niosomes made up of ,-hexadecyl-bis- (1-aza-18-crown-6) (bola), Span 80(R), cholesterol and N- (carbonyl-methoxypolyethylene glycol-2000)-1,2- distearoyl-sn-glycero-3-phosphoethanolamine (DSPEMPEG 2000) (2:5:2:0.1 molar ratio) are proposed as suitable delivery systems for the administration of 5- fluorouracil (5-FU), an antitumoral compound largely used in the treatment of breast cancer. In vitro cytotoxic tests on MCF-7 and T47D cells and in vivo experiments on MCF-7 xenograft tumor SCID mice models showed a more effective antitumoral activity of the 5-FU-loaded PEGylated niosomal with respect to the free drug.