Pharmacological availability of orally administered insulin insulin-loaded gelatin nanoparticles in diabetic rats

摘要

Biologically and conformationally stable I insulin nsulin- loaded gelatin nanoparticles (NPs) were prepared and evaluated as a vehicle for the oral delivery of insulin in diabetic rats. Results show that at 50 IU/kg dose, orally t delivered insulin insulin-loade loaded NPs d lowered basal blood gluco glucose se levels in diabetic rats by 37 % and sustained hypoglycemia for over 12 h. Pha Pharmacological availability macological (PA) was 6.1 %, a significant increase over 1.4 % determined for oral insulin alone in solution. Encapsulation of in insulin into gelatin NPs sulin was observed to be a key factor in the improved bioavailability over insulin solution.