Polymerized liposomes have been studied in recent years as stable biomembrane model and drug delivery system. Among these liposomes, the amphiphiles having unsaturated carbon-carbon bonds, such as diyne or diene can be polymerized by UV irradiation and result in the stabilization of the self-assemblied structures while preserving their morphological features. However, the resulting polyolfins after addition polymerization are difficult to degrade in vivo, and sometimes even cause toxic, which greatly limit their uses as drug carriers. Condensable liposomes from amphiphilic amino acids as potential biodegradable drug carriers, can form a polypeptide net on their surface through condensation polymerization, which may increase their biocompability and half life time in vivo. In this paper, a novel kind of amphiphilic amino acid S-[l-carboxy-2-([N-(l,2-bisoctadecyloxycarbonyl )ethyl] carbanoyl ) ethyl] cysteine (Asp18-M-Cys) was synthesized and the formation of stable liposome was confirmed. It can be polymerized in lipid bilayer membrane and change the stability and permeability of the liposomes .
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