(Invited) Understanding the Role of Protein Corona on Oligonucleotide Recognition Efficiency in Fluorescent Flares

摘要

Nanoparticle-based biosensors are developed and implemented to address a wide range of biomedical questions in bioimaging, molecular diagnostics, targeted drug delivery and controlled release, or photothermal cancer therapy. In this respect, gold nanoparticles provide physicochemical and optical properties that make them particularly interesting. Their relevant, and often unique, plasmonic response has enabled their integration with various transduction modalities (e.g. colorimetric, fluorescence, Raman) and led to the development of extremely sensitive and selective detection platforms. Added advantages associated with gold nanoparticles are their excellent biocompatibility and low toxicity compared to some other nanomaterials (notably quantum dots and silver nanoparticles) when used for sensing and imaging purposes in vivo.