Anodic Oxidation of Bisamides

摘要

Previously we studied the anodic oxidation of bisamides of type RCONH(CH_2)_n NHCOR (n = 2-4) under controlled current electrolysis (CCE), in methanol. Those with 3 and 4 methylene groups undergo mostly mono- and dimethoxylation at the alpha-position to 'N' atom. However, when the spacer contains two methylene groups only the anodic process favor fragmentation products due to CH_2-CH_2 bond cleavage, as shown in Eq. 1.