(Invited) Laser-Engraved Lab on the Skin for Metabolic and Nutritional Monitoring

摘要

Wearable sensors offer tremendous potential for biomedical applications. Sweat analysis is an attractive candidate that enables continuous and non-invasive molecular monitoring of circulating metabolites and nutrients. However, existing wearable sweat sensing platforms are primarily focused on a limited number of electrolytes and metabolites monitored via ion selective or enzymatic electrodes. Moreover, they either lack multimodal sensing functionality or require expensive micro/nanofabrication facilities. Here we report a mass-producible, all-laser-engraved graphene sensor that enables highly sensitive sweat analysis and multiplexed vital sign monitoring. We demonstrate in situ continuous uric acid and tyrosine monitoring in human perspiration during exercise in both physically trained and untrained subjects. The use of this platform for non-invasive gout management is evaluated on clinically diagnosed gout patients and via a purine-rich meal challenge on healthy individuals. This flexible graphene sensor demonstrates great promise for noninvasive, personalized metabolic and nutritional management.