Physical Properties and Irritation Index Essential Oil of Clove (Syzigium aromaticum) in Absorption Base Ointment with Variation Concentration

摘要

The essential oil of clove (Syzygium aromaticum) contains eugenol which has antiinflammatory activity. Development of the dosage form for this essential oil was needed to increase its acceptability. The aim of this study was to know the influence of concentration variations of the essential oil of Syzigium aromaticum in an absorption ointment base to the physical properties and irritation index of the ointment. The ointment was formulated by melting method. The concentrations of essential oil were 2,5% (FI), 5% (FII) and 10% (FIII), respectively. The ointment was evaluated for its physical properties (spreadability, adhesivity and pH) and irritation index. Data were analyzed by anovaone way with 95% confidence level. The results of this study showed that the concentration variation) of essential oil of Syzygium aromaticum influenced the physical properties except pH. The increasing concentration of essential oil of Syzygium aromaticum caused increasing spreadability and decreasingadhesivity. On the other hand the concentration variationof essential oil did not influence the irritation index of the ointment. The irritation index of the ointment was negigible.