Synthesis and DNA binding study of Zinc (II) co-ordination complexes

摘要

Since the discovery of cisplatin, transitional metal complexes have been the focus for their potential biological applications. Recently their role as DNA intercalating agents has been proved. As zinc is an active core of binding site of some metalloenzymes, the synthesis of structurally similar zinc (II) complexes is in the offing. They are found to be potent DNA intercalating and cleaving agents. Thus, the current study is focused on synthesis of zinc (II) complexes using amino acid / schiff bases as ligands. The complexes are characterized by FTIR, UV-Visible and mass spectral studies and assessed for their DNA binding study using λ DNA by agarose gel electrophoresis.