Selective C-P Bond Cleavage of Phosphine Oxides by Sodium

摘要

Trivalent phosphines R3P are frequently used in numerous classic organictransformations such as Witting reaction,Mitsunobu reaction,Appel reaction and so on.Furthermore,they are widely applied in most transition-metal catalyzed reactions as ligandsdue to their excellent metal ligation properties.1 However,these processes are usually endedup with formation of the corresponding phosphine oxides that are chemically stable anddiscarded as useless wastes.Up to date,the reductions of phosphine oxides to phosphineshave been the most common solutions by using excess of reductants such as Si-H or Al-Hreagents,however,these procedures require sensitive and highly expensive reducing agentsand harsh reaction conditions.