Stability of phase-separated structures in biomimetic membraneswith Vitamin E

摘要

Vitamin E (VE),antioxidant,is fat-soluble.α-Tocopherol (toc),a well-known form of VE,can suppress neural cell death induced by ER stress [1].On the other hand,α-tocotrienol (toc3),another form of VE,which is different from toc only in hydrocarbon structure cannot suppressit.The reason that toc and toc3 show different functions is not clear.Since toc and toc3 arehydrophobic molecules,they can exist in the hydrophobic region of biological membranes.Wehypothesis that the functional difference between toc and toc3 arises from the difference in theintermolecular interaction in biological membranes.