Direct observation of nucleosome interaction in DNA frame usinghigh-speed AFM

摘要

Nucleosome is a basic unit of eukaryotic chromatin.Nucleosome core particle contains ahistone octamer core,which is consisted of two pairs of histone protein,H2A,H2B,H3 andH4,wrapped with double-stranded DNA.1 The nucleosome position on genomic DNA andhistone modification play an important role in gene expression and regulation.Chromatinstructure and organization are related to gene activation and repression.Nucleosome structureand interaction affect chromatin structure in order to regulate epigenetic function.